ModifiedReceptorInternalizationuponCoexpressionof5-HT1BReceptorand5-HT2BReceptors
【关键词】ModifiedSerotonin5-HT2Breceptorsareoftencoexpressedwith5-HT1Breceptors,andcross-talkbetweenthetworeceptorshasbeenreportedinvariouscelltypes.However,manymechanisticdetailsunderlying5-HT1Band5-HT2Breceptorcross-talkhavenotbeenelucidated.Wehypothesizedthat5-HT2Band5-HT1Breceptorseachaffe...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第6期CharacterizationoftheNovelHumanSerotoninReceptorSubunits5-HT3C,5-HT3D,and5-HT3E
...acterizationWithinthefamilyofserotoninreceptors,the5-hydroxytryptamine-3(5-HT3)receptoristheonlyligand-gatedionchannel.Itiscomposedoffivesubunits,ofwhichthe5-HT3Aand5-HT3Bsubunitsarebestcharacterized.Severalstudies,however,havereportedonthefunctionaldiversityofnative5-HT3receptors,whichcannotsolelyb...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第7期AnandamideInhibitionof5-HT3AReceptorsVarieswithReceptorDensityandDesensitization
...GICs.Here,wereportthatAEAinhibitedthefunctionofserotoningatedionchannels(5-HT3A)expressedinXenopuslaevisoocytesandhumanembryonickidney293cellsinamannerthatwasdependentonthesteady-statereceptordensityatthecellsurface.ThemagnitudeofAEAinhibitionwasinverselycorrelatedwiththeexpressionlevelsofreceptorpr...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第2期SerotoninInhibitsNeuronalExcitabilitybyActivatingTwo-PoreDomainK+ChannelsintheEntorhinalCortex
...ftheECbyactivatingtheTWIK-1typeofthetwo-poredomainK+channels.Theeffectsof5-HTweremediatedvia5-HT1AreceptorsandrequiredthefunctionofGi3subunitandproteinkinaseA.Serotonin-mediatedinhibitionofECactivityresultedinaninhibitionofhippocampalfunction.Ourstudyprovidesacellularmechanismthatmightatleastpartial...
医源资料库;在线期刊;分子药理学杂志;2007年第69卷第7期RisperidoneIrreversiblyBindstoandInactivatestheh5-HT7SerotoninReceptor
...键词】RisperidoneRisperidonedisplaysanovelmechanismofantagonismoftheh5-HT7receptor.Pretreatmentofthecellswith5or20nMrisperidone,followedbyremovalofthedrugfromthemedia,rendersthe5-HT7receptorsunresponsiveto10µM5-HTforatleast24h.Thus,risperidoneseemstobeproducingarapid,long-lastinginactivatio...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第10期PharmacologicalCharacterizationofSerotonergicReceptorActivityintheHypoglossalNucleus
...essedthedose–responsecurveforthe2Cagonist.Rapiddesensitizationoccurredwiththe2Cagonistonly(p0.05).The7antagonist,SB-269,970,hadnoeffectoneitherintrinsicactivityoragonistresponses.Weconcludethatserotonin2Aisthepredominantexcitatoryserotoninreceptorsubtypeathypoglossalmotorneurons.Theserotonin2Cexci...
医源资料库;在线期刊;美国呼吸和危急护理医学;2003年第167卷第4期DualSerotonergicRegulationofVentricularContractileForceThrough5-HT2Aand5-HT4ReceptorsInducedintheAcuteFailingHeart
...leftventriclehasbecomesensitivetoserotoninbecauseofappearanceofGs-coupled5-HT4receptors.WhetherthisalsooccursinacuteCHFisunknown.Serotoninresponsivenessmaydevelopgraduallyorrepresentanearlyresponsetotheinsult.Furthermore,serotoninreceptorexpressioncouldvarywithprogressionofthedisease.PostinfarctionC...
医源资料库;在线期刊;循环研究杂志;2005年第95卷第8期MolecularDeterminantsfortheInteractionoftheValvulopathicAnorexigenNorfenfluraminewiththe5-HT2BReceptor
...e-threateningcardiovascularsideeffects.SNFreducesappetitethroughserotonin5-HT2Creceptoractivation;itcausescardiopulmonarysideeffectsthrough5-HT2Breceptoractivation.Thus,weattemptedtoidentifymoleculardeterminantsofSNFbindingto5-HT2BreceptorsdistinctfromthoseunderlyingSNF-5-HT2C/2Areceptorinteractions...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第1期RegionalDifferencesintheCouplingof5-Hydroxytryptamine-1AReceptorstoGProteinsintheRatBrain
...词】5-Hydroxytryptamine-1ANumerousdatashowedthat5-hydroxytryptamine-1A(5-HT1A)receptorscoupletoGo/iproteinsforsignaltransduction.However,thesubunitisoformsreallyinvolvedin5-HT1Areceptorcouplinginbrainremaintobeidentified.Moreover,regionaldifferencesinthefunctionalcharacteristicsofbrain5-HT1Arecept...
医源资料库;在线期刊;分子药理学杂志;2006年第68卷第9期InverseAgonistandNeutralAntagonistActionsofAntidepressantsatRecombinantandNative5-Hydroxytryptamine2CReceptors:DifferentialModulationofCellS
【关键词】InverseDespitetheimportanceof5-hydroxytryptamine(5-HT)2C(serotonin)receptorsinthecontrolofdepressivestates,actionsofantidepressantsatthesereceptorsremainpoorlycharacterized.Thisissuewasaddressedbothinhumanembryonickidney(HEK)-293cellscoexpressinguneditedhuman5-HT2CINIreceptorsandGqpro...
医源资料库;在线期刊;分子药理学杂志;2008年第70卷第3期